Hydroxyproline (Total Collagen) Assay Kit
Product Sizes
96 wells
£882.00
ARG82320-96WELLS
About this Product
- SKU:
- ARG82320
- Additional Names:
- OI1; OI2; OI3; OI4; EDSC; Collagen alpha-1(I) chain; Alpha-1 type I collagen
- Application:
- Cell-based/Functional Assay
- CE/IVD:
- RUO
- Extra Details:
- This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
- Immunogen:
- Hydroxyproline (Total Collagen)
- Physical State:
- Cell Lysate, Tissue Extract
- Reactivities:
- Human, Mouse, Other Mammal, Rat
- Sensitivity:
- 2.5 ug/ml
- Shipping Conditions:
- Blue Ice
- Specificity:
- The kit is based on the detection of hydroxyproline. Hydroxyproline is a non-proteinogenic amino acid, which in mammals occurs in elastin and collagen. Its presence is mainly limited to the triple helix of collagen, where its presence increases the triple helix stability. Hydroxyproline is formed posttranslationally from specific proline residues by action of the enzyme prolylhydroxylase. Hydroxyp
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Assay Kits: Detection
- Manufacturer's Data Sheet:ARG82320.html
