Human IL33 ELISA Kit
Product Sizes
96 wells
£490.00
ARG80179-96WELLS
About this Product
- SKU:
- ARG80179
- Additional Names:
- 95-270; NF-HEV; Interleukin-33; C9orf26; IL1F11; 99-270; Interleukin-1 family member 11; IL-33; IL-1F11; Nuclear factor from high endothelial venules; NFEHEV; DVS27; 109-270
- Application:
- ELISA
- CE/IVD:
- RUO
- Conjugate:
- HRP
- Extra Details:
- Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1a/b, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-kB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.
- Immunogen:
- IL33
- Physical State:
- Cell Culture Supernatant, Plasma, Serum
- Reactivities:
- Human
- Sensitivity:
- 8 pg/ml
- Shipping Conditions:
- Blue Ice
- Specificity:
- No significant cross-reactivity or interference with Human IL-1A Alpha, IL-1B Beta, IL-18, IL-36A Alpha,IL-36B Beta, IL-37
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Assay Kits: ELISAs
- Manufacturer's Data Sheet:ARG80179.html
