anti-CD45R / B220 antibody [RA3-6B2] (low endotoxin)
Product Sizes
100 ug
£477.00
ARG65533-100UG
About this Product
- SKU:
- ARG65533
- Additional Names:
- LY5; GP180; Receptor-type tyrosine-protein phosphatase C; CD45; L-CA; CD antigen CD45; Leukocyte common antigen; CD45R; LCA; T200; EC 3.1.3.48; B220
- Application:
- Cell-based/Functional Assay, Flow Cytometry, IHC-Frozen, IHC-Paraffin, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
- Buffer:
- PBS (pH 7.4)
- CE/IVD:
- RUO
- translate.label.attr.clone:
- RA3-6B2
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
- Host:
- Rat
- Immunogen:
- Abelson murine leukemia virus-induced pre-B tumor cells
- Isotype:
- IgG2a
- Purity:
- >95%
- Purification:
- Protein G Purified
- Reactivities:
- Feline, Human, Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- The clone RA3-6B2 recognizes an epitope on CD45R, which is expressed at all developmental stages of B cells, including activated B cells, but also on subsets of NK and T cells. T cells detected by this antibody are supposed to be in activated state.
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG65533.html
