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Antibodies

anti-COX1 antibody

Product Sizes
100 ug
£616.00
ARG63193-100UG
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG63193
Additional Names:
Prostaglandin H2 synthase 1; COX-1; PHS1; Cyclooxygenase-1; PGHS1; COX3; COX1; PGG/HS; PTGHS; PES-1; EC 1.14.99.1; PHS 1; Prostaglandin-endoperoxide synthase 1; PGHS-1; PCOX1; PGH synthase 1; Prostaglandin G/H synthase 1
Application:
Immunocytochemistry, Immunofluorescence, Western Blot
Buffer:
Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA.
CE/IVD:
RUO
Clonality:
Polyclonal
Concentration:
0.5 mg/ml
Extra Details:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq, Jul 2008]
Host:
Goat
Immunogen:
C-QDDGPAVERPSTEL
Isotype:
IgG
Purification:
Purified from goat serum by antigen affinity chromatography.
Reactivities:
Human, Mouse
Shipping Conditions:
Blue Ice
Specificity:
This antibody is expected to recognise both human isoforms of this protein according to NP_000953.2 and NP_542158.1.
Storage Conditions:
-20[o]C
Supplier:
Arigo Biolaboratories
Type:
Antibody: Polyclonal Antibody
Western blot: HeLa lysate (RIPA buffer, 30ug total protein per lane) stained with ARG63193 anti-COX1 antibody at 1 ug/ml dilution.
Immunofluorescence: Paraformaldehyde fixed NIH/3T3 cells permeabilized with 0.15% Triton. Cells were stained with ARG63193 anti-COX1 antibody (green) at 5 ug/ml dilution for 1 hour. DAPI (blue) for nuclear staining. Negative control: Unimmunized goat IgG (green) at 5 ug/ml dilution.
Western blot: 35 ug of U937 cell lysate (in RIPA buffer) stained with ARG63193 anti-COX1 antibody at 2 ug/ml dilution and incubated at RT for 1 hour.
Western blot: 35 ug of Mouse kidney (A) and skeletal muscle (B) lysates (in RIPA buffer) stained with ARG63193 anti-COX1 antibody at 0.5 ug/ml dilution and incubated at RT for 1 hour.