anti-CD47 antibody [MEM-122] (FITC)
Product Sizes
100 tests
£493.00
ARG62872-100TESTS
About this Product
- SKU:
- ARG62872
- Additional Names:
- Leukocyte surface antigen CD47; CD antigen CD47; Antigenic surface determinant protein OA3; MER6; OA3; Protein MER6; IAP; Integrin-associated protein
- Application:
- Flow Cytometry
- Buffer:
- TBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-122
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- CD47 (integrin-associated protein, IAP) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
- Host:
- Mouse
- Immunogen:
- COS-7 (African green monkey) cells
- Isotype:
- IgM
- Reactivities:
- Human, Non-human Primate, Porcine
- Shipping Conditions:
- Blue Ice
- Specificity:
- The clone MEM-122 reacts with CD47 (Integrin Associated Protein), a 50-55 kDa membrane adhesion molecule (thrombospondin receptor; immunoglobulin supergene family) expressed on leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines.HLDA VI; WS Code AS A051
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG62872.html
