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Antibodies

anti-CD47 antibody [MEM-122]

Product Sizes
100 ug
£477.00
ARG62871-100UG
Academic Pricing
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About this Product
SKU:
ARG62871
Additional Names:
Leukocyte surface antigen CD47; CD antigen CD47; Antigenic surface determinant protein OA3; MER6; OA3; Protein MER6; IAP; Integrin-associated protein
Application:
Flow Cytometry, IHC-Frozen, Western Blot
Buffer:
TBS (pH 8.0) and 15 mM Sodium azide
CE/IVD:
RUO
translate.label.attr.clone:
MEM-122
Clonality:
Monoclonal
Concentration:
1 mg/ml
Extra Details:
CD47 (integrin-associated protein, IAP) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
Host:
Mouse
Immunogen:
COS-7 (African green monkey) cells
Isotype:
IgM
Purity:
>95%
Purification:
Purified
Reactivities:
Human, Non-human Primate, Porcine
Shipping Conditions:
Blue Ice
Specificity:
The clone MEM-122 reacts with an extracellular epitope of CD47 (Integrin Associated Protein), a 50-55 kDa membrane adhesion molecule (thrombospondin receptor; immunoglobulin supergene family) expressed on leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines.HLDA VI; WS Code AS A051
Storage Conditions:
-20[o]C
Supplier:
Arigo Biolaboratories
Type:
Antibody: Monoclonal Antibody
Flow Cytometry: Porcine peripheral blood stained with ARG62871 anti-CD47 antibody [MEM-122], followed by incubation with FITC-labelled secondary antibody. Panel A was stained with Isotype mouse IgM control.