anti-CD22 antibody [MEM-01]
Product Sizes
50 ug
£349.00
ARG62775-50UG
100 ug
£477.00
ARG62775-100UG
About this Product
- SKU:
- ARG62775
- Additional Names:
- B-lymphocyte cell adhesion molecule; B-cell receptor CD22; T-cell surface antigen Leu-14; BL-CAM; SIGLEC-2; Sialic acid-binding Ig-like lectin 2; Siglec-2; CD antigen CD22; SIGLEC2
- Application:
- Flow Cytometry, Immunoprecipitation, Western Blot
- Buffer:
- PBS (pH 7.4) and 15 mM Sodium azide
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MEM-01
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.
- Host:
- Mouse
- Immunogen:
- Raji Burkitt's lymphoma cell line
- Isotype:
- IgG1
- Purity:
- >95%
- Purification:
- Protein A Purified
- Reactivities:
- Human, Non-human Primate
- Shipping Conditions:
- Blue Ice
- Specificity:
- The clone MEM-01 reacts with CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes. MEM-01 cross-blocks the antibody OTH228 that recognizes uniquely epitope "E";
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG62775.html
