anti-S6 Ribosomal Protein phospho (Ser 244) antibody
Product Sizes
50 ul
£456.00
ARG52419-50UL
About this Product
- SKU:
- ARG52419
- Additional Names:
- Phosphoprotein NP33; 40S ribosomal protein S6; S6
- Application:
- Western Blot
- Buffer:
- 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Extra Details:
- Ribosomal protein S6 (rpS6) is a critical component of the 40 S ribosomal subunit that mediates translation initiation at the 5'-m7 GpppG cap of mRNA. The rpS6 protein is both cytoplasmic and nuclear localized (Chen and Dittmer 2011). In response to mitogenic stimuli, rpS6 undergoes ordered C-terminal phosphorylation by p70 S6 kinases and p90 ribosomal S6 kinases on four Ser residues (Ser-235, Ser-236, Ser-240, and Ser-244) whose modification potentiates rpS6 cap binding activity (Hutchinson et al., 2011). Additionally, rpS6 phosphorylation and function are highly regulated and have been implicated in the regulation of translational initiation and protein synthesis in response to extracellular stimuli such as TRAIL and gamma interferon (IFN-G Gamma), as well as upon activation of the phosphatidylinositol 3-kinase (PI3K)-Akt-mTOR pathway (Chen and Dittmer 2011).
- Host:
- Rabbit
- Immunogen:
- Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser244 conjugated to KLH
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Amphibian, Avian, Fish, Guinea Pig, Human, Mouse, Non-human Primate, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ARG52419.html
