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Antibodies

anti-IFNAR1 phospho (Ser535 / Ser539) antibody

Product Sizes
50 ul
£456.00
ARG52325-50UL
Academic Pricing
Please contact us for academic pricing.
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About this Product
SKU:
ARG52325
Additional Names:
Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFRC; IFNAR; AVP; IFN-alpha/beta receptor 1; CRF2-1; IFN-R-1; Type I interferon receptor 1; IFNBR; Interferon alpha/beta receptor 1; IFN-alpha-REC
Application:
IHC-Paraffin, Western Blot
Buffer:
10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
CE/IVD:
RUO
Clonality:
Polyclonal
Extra Details:
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-A Alpha Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
Host:
Rabbit
Immunogen:
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 conjugated to KLH
Isotype:
IgG
Purification:
Affinity Purified
Reactivities:
Bovine, Canine, Human, Mouse, Non-human Primate, Rat, Sheep
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Supplier:
Arigo Biolaboratories
Type:
Antibody: Polyclonal Antibody
Western blot: Immunoprecipitates from HEK 293 cells transfected with 1. Mock 2. IFNAR1 WT and 3. IFNAR1 Ser 535 Arg and Ser 539 Arg mutants stained with ARG52325 anti-IFNAR1 phospho (Ser535 / Ser539) antibody.The immunolabeling is absent in the IFNAR1 Ser 535 and Ser 539 mutants. The labeling is blocked by the phosphopeptide (Phos) used as the antigen but not by the dephosphopeptide (Dephos).Iimmunoprecipitates from HEK 293 cells transfected with 1. Mock, 2. IFNAR1 WT, and 3. IFNAR1 S535A and S539A mutants showing specific immunolabeling of the ~110k to ~130k IFNAR1 WT. The immunolabeling is absent in IFNAR1 Ser535 and Ser539 mutants (Control). The immunolabeling is blocked by the phosphopeptide (Phos) used as the antigen but not by the corresponding dephosphopeptide (Dephos).