anti-KIR3DL3 / CD158z antibody [CH21]
Product Sizes
100 ug
£477.00
ARG43862-100UG
About this Product
- SKU:
- ARG43862
- Additional Names:
- KIR3DL3; Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3; KIR3DL7; CD158Z; KIRC1; KIR44; Killer Cell Immunoglobulin-Like Receptor, Three Domains, Long Cytoplasmic Tail, 3; Killer Cell Immunoglobulin-Like Receptor 3DL3; CD158 Antigen-Like Family Member Z; Killer Cell Inhibitory Receptor 1; KIR3DL3 Killer-Cell Immunoglobulin-Like Receptor; Killer-Cell Immunoglobulin-Like Receptor 3DL3; Killer Cell Ig-Like Receptor KIR3DL7; KIR2DS2*00101-V; KIR3DL3*01403-V; CD158z Antigen; KIR2DS2
- Application:
- Flow Cytometry, Immunoprecipitation
- Buffer:
- PBS (pH 7.4) and 15 mM Sodium azide
- translate.label.attr.clone:
- CH21
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.
- Host:
- Mouse
- Immunogen:
- Human KIR3DL3 / CD158z transfectants
- Isotype:
- IgG2a
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG43862.html
