anti-PRKAR2A / PKR2 antibody [Hs-36]
Product Sizes
100 ug
£477.00
ARG42439-100UG
About this Product
- SKU:
- ARG42439
- Additional Names:
- cAMP-dependent protein kinase type II-alpha regulatory subunit; PRKAR2; PKR2
- Application:
- Immunocytochemistry, Immunofluorescence, Western Blot
- Buffer:
- TBS and 15 mM Sodium azide.
- CE/IVD:
- RUO
- translate.label.attr.clone:
- Hs-36
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
- Host:
- Mouse
- Immunogen:
- Freshly ejaculated Human sperms were washed in PBS and extracted in 3% acetic acid, 10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0.2% acetic acid and subsequently used for immunization.
- Isotype:
- IgM
- Purification:
- Purified
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- The antibody Hs-36 reacts with PRKAR2A (protein kinase A regulatory type II alpha subunit), an intra-acrosomal protein.
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:ARG42439.html
