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Antibodies

anti-IKZF1 / Ikaros antibody [4E9] (PE)

Product Sizes
50 tests
£408.00
ARG42282-50TESTS
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About this Product
SKU:
ARG42282
Additional Names:
IK1; Hs.54452; LYF1; PPP1R92; LyF-1; Lymphoid transcription factor LyF-1; IKAROS; Ikaros family zinc finger protein 1; DNA-binding protein Ikaros; PRO0758; ZNFN1A1
Application:
Flow Cytometry
Buffer:
PBS and 15 mM Sodium azide.
CE/IVD:
RUO
translate.label.attr.clone:
4E9
Clonality:
Monoclonal
Conjugate:
R-PE
Extra Details:
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
Host:
Mouse
Immunogen:
Recombinant Human Ikaros (C-terminal part).
Isotype:
IgG1
Purification:
Purified
Reactivities:
Human, Mouse
Shipping Conditions:
Blue Ice
Specificity:
The mouse monoclonal antibody 4E9 recognizes Ikaros, a transcription factor (intracellular antigen) expressed broadly in hematopoietic progenitors and serving as a key regulator of lymphopoiesis.
Storage Conditions:
2-8[o]C
Supplier:
Arigo Biolaboratories
Type:
Antibody: Monoclonal Antibody
Flow Cytometry: Human peripheral blood leukocytes stained with ARG42282 anti-IKZF1 / Ikaros antibody [4E9] (PE) and anti-CD3 antibody (FITC).