anti-NIK antibody
Product Sizes
50 ug
£350.00
ARG20457-50UG
About this Product
- SKU:
- ARG20457
- Additional Names:
- NIK; HSNIK; FTDCR1B; HS; EC 2.7.11.25; HsNIK; Serine/threonine-protein kinase NIK; NF-kappa-beta-inducing kinase; Mitogen-activated protein kinase kinase kinase 14
- Application:
- Western Blot
- Buffer:
- PBS (pH 7.2), 50% Glycerol, 1% BSA and 0.02% Thimerosal
- CE/IVD:
- RUO
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- NIK (NF-kB-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-kB activity. NIK was initially isolated from a human B cell cDNA library and contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to IkB phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kB activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-kB activation.
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide around 927 aa of Human NIK protein (NP_003945.2)
- Isotype:
- IgG
- Purification:
- Affinity Purified
- Reactivities:
- Canine, Hamster, Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C
- Supplier:
- Arigo Biolaboratories
- Type:
- Antibody: Polyclonal Antibody
- Manufacturer's Data Sheet:ARG20457.html
