Anti-DNA-RNA Hybrid Antibody(S9.6)
Product Sizes
100 ug
£384.00
RGK60001-100UG
1 mg
£1304.00
RGK60001-1MG
About this Product
- SKU:
- RGK60001
- Additional Names:
- DNA-RNA Hybrid
- Application:
- ChIP, Dot Blot, FISH, Gel Shift/EMSA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Surface Plasmon Resonance
- Buffer:
- 0.01M PBS, pH 7.4.
- translate.label.attr.clone:
- S9.6
- Clonality:
- Monoclonal
- Concentration:
- 0.58 mg/ml
- Extra Details:
- DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. A locus forming an DNA:RNA creates a double-stranded A/B intermediate conformation, with a second target for single-stranded nucleic acid binding proteins on the complementary, displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia oculomotor apraxia type 2.
- Host:
- Mouse
- Immunogen:
- DNA-RNA Hybrid
- Isotype:
- IgG2a, kappa
- Physical State:
- Liquid
- Purity:
- >95%
- Purification:
- Protein A/G purified from cell culture supernatant.
- Reactivities:
- Wide/Non-species Specific
- Shipping Conditions:
- Blue Ice
- Source:
- Mammalian cells
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- AntibodySystem
- Type:
- Antibody: Monoclonal Antibody
- Manufacturer's Data Sheet:7992.html
