RecombinantHumanPCSK9(Asp374Tyr)Protein,C-His
Product Sizes
50 ug
£232.00
EHJ24002-50UG
100 ug
£487.00
EHJ24002-100UG
1 mg
£2005.00
EHJ24002-1MG
About this Product
- SKU:
- EHJ24002
- Additional Names:
- Proproteinconvertasesubtilisin/kexintype9,Subtilisin/kexin-likeproteasePC9,NARC-1,PC9,Proproteinconvertase9,Neuralapoptosis-regulatedconvertase1,NARC1,PCSK9
- Application:
- ELISA, SDS-PAGE, Western Blot
- Buffer:
- LyophilizedfromasolutioninPBSpH7.4,1mMEDTA,4%Trehalose,1%Mannitol.
- Extra Details:
- GeneticvariationinPCSK9hasanenormousimpactonLDL-Cconcentrationinhumansandbothgain-of-function(GOF)andloss-of-function(LOF)PCSK9mutationshavebeendescribed.WhilePCSK9LOFmutationscausehypocholesterolemia,GOFmutationsareararecauseoffamilialhypercholesterolemia(FH),amonogenicdiseasecharacterizedbyveryhighlevelsofLDL-Candprematureatheroscleroticcardiovasculardisease(ASCVD).PCSK9GOFmutationsarecausativeofFH,becausetheenhancementinPCSK9functionleadstoincreasedLDLrdegradationandreducedrecyclingtothecellsurface.Asaconsequence,thereisareductioninLDLuptakeandanincreaseincirculatingLDL-Cconcentration.ThebestcharacterizedPCSK9GOFmutationisp.(Asp374Tyr)whichproducesaten-foldincreaseinLDLrdegradationbyincreasingthebindingaffinityofPCSK9totheepidermalgrowthfactor-likedomainofLDLr.ThisvariantwasdemonstratedtoinhibitLDLuptakestillataconcentration25timeslowerthanthewild-typePCSK9.
- Molecular Weight:
- 75.30kDa
- Physical State:
- Lyophilized
- Purity:
- >90% as determined by sds-page.
- Shipping Conditions:
- Dry Ice
- Source:
- Mammalian cells
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- AntibodySystem
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
- Manufacturer's Data Sheet:15021.html
