Research Grade Varlilumab
Product Sizes
5 mg
£ POA
DHD72201-5MG
1 mg
£506.00
DHD72201-1MG
25 mg
£4027.00
DHD72201-25MG
About this Product
- SKU:
- DHD72201
- Additional Names:
- 1F5, CDX-1127, CAS: 1393344-72-3
- Buffer:
- 0.01M PBS, pH 7.4.
- translate.label.attr.clone:
- Varlilumab
- Clonality:
- Recombinant Monoclonal
- Concentration:
- 2 mg/ml
- Extra Details:
- Varlilumab is a fully human monoclonal antibody (mAb) that targets CD27, a critical molecule in the activation pathway of lymphocytes. Like CD40, CD27 can be effectively manipulated with activating antibodies to induce potent anti-tumor responses, and may result in less toxicities due to its restricted expression and regulation. Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumor activity in tumor models. This first-in-human, dose-escalation and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients with advanced solid tumors.
- Host:
- Human
- Immunogen:
- CD27L receptor, TNFRSF7, T14, CD27 antigen, Tumor necrosis factor receptor superfamily member 7, CD27, T-cell activation antigen CD27
- Isotype:
- IgG1, kappa
- Physical State:
- Liquid
- Purity:
- >95%
- Purification:
- Protein A/G purified from cell culture supernatant.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Source:
- XtenCHO
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- AntibodySystem
- Type:
- Antibody: Recombinant Antibodies
- Manufacturer's Data Sheet:151.html
