Recombinant Human BP180/NC16a Protein
Product Sizes
50 ug
£168.00
AID00701-50UG
100 ug
£327.00
AID00701-100UG
1 mg
£1145.00
AID00701-1MG
About this Product
- SKU:
- AID00701
- Additional Names:
- LinearIgAdiseaseantigen1,COL17A1,180kDabullouspemphigoidantigen2,LAD-1,LinearIgAbullousdiseaseantigenof97kDa,120kDalinearIgAdermatosisantigen,97-LAD,Collagenalpha-1(XVII)chain,Bullouspemphigoidantigen2,97kDalinearIgAbullousdermatosisantigen,LABD97,97kDaLADantigen,BPAG2,BP180
- Buffer:
- LyophilizedfromasolutioninPBSpH7.4,0.02%NLS,1mMEDTA,4%Trehalose,1%Mannitol.
- Extra Details:
- BullouspemphigoidistheresultofanattackonthebasementmembraneoftheepidermisbyIgG+/-IgEimmunoglobulins(antibodies)andactivatedTlymphocytes(whitebloodcells).ThetargetistheproteinBP180(alsocalledTypeXVIIcollagen),orlessfrequentlyBP230(aplakin).TheseproteinsarewithintheNC16AdomainofcollagenXVII.Theyareassociatedwiththehemidesmosomes,structuresthatensuretheepidermalkeratinocytecellssticktothedermistomakeawaterproofseal.ThebindingoftheautoantibodiestotheproteinsandreleaseofcytokinesfromtheTcellsleadtocomplementactivation,recruitmentofneutrophils(acuteinflammatorycells)andthereleaseofproteolyticenzymes.Thesedestroythehemidesmosomesandcausetheformationofsubepidermalblisters.
- Physical State:
- Lyophilized
- Purity:
- >95% as determined by sds-page.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- AntibodySystem
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
