Human WEE1 Protein, His Tag (active enzyme)
Product Sizes
100 ug
£954.00
WE1-H5543-100UG
1 mg
£2979.00
WE1-H5543-1MG
About this Product
- SKU:
- WE1-H5543
- Buffer:
- 50 mM Tris, 300 mM NaCl, pH7.5
- Extra Details:
- WEE1 is a serine/threonine protein kinase that acts as a critical regulator of the cell cycle , particularly at the G₂/M checkpoint . It inhibits cell cycle progression by phosphorylating and inactivating CDK1 (Cyclin-Dependent Kinase 1) at Tyr15, thereby preventing premature entry into mitosis and allowing time for DNA repair.Originally identified in fission yeast, WEE1 is highly conserved in mammals and plays a key role in maintaining genomic stability. Dysregulation of WEE1 is linked to cancer progression , as its overexpression in tumors (e.g., ovarian, breast, pancreatic cancers) supports cancer cell survival by enabling DNA damage tolerance. This dependency makes WEE1 a promising therapeutic target , especially in p53-mutant cancers where inhibiting WEE1 induces synthetic lethality by forcing cells with unrepaired DNA into catastrophic mitosis.
- Immunogen:
- WEE1
- Molecular Weight:
- 51.1 kDa
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
