Human Tyk2 Protein, His Tag
Product Sizes
100 ug
£913.00
TY2-H5548-100UG
1 mg
£2703.00
TY2-H5548-1MG
About this Product
- SKU:
- TY2-H5548
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Extra Details:
- Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-A Alpha, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-A Alpha and -B Beta and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
- Immunogen:
- Tyk2
- Molecular Weight:
- 35.2 kda
- Physical State:
- Liquid
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -70[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
