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Proteins and Peptides

Cynomolgus TSPAN8 Protein, His Tag

Product Sizes
100 ug
£377.00
TS8-C5247-100UG
1 mg
£2461.00
TS8-C5247-1MG
About this Product
SKU:
TS8-C5247
Buffer:
PBS
Extra Details:
Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form 'tetraspanin webs'. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell-cell and cell-matrix interactions through its association with membrane partners such as A Alpha6B Beta4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.
Immunogen:
TSPAN8
Molecular Weight:
12.7 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Cynomolgus TSPAN8, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Cynomolgus TSPAN8, His Tag (Cat. No. TS8-C5247) at 1 ug/mL (100 uL/well) can bind Anti-TSPAN8 mIgG2b Antibody with a linear range of 0.008-5 ug/mL (Routinely tested).