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Proteins and Peptides

Human TRAIL / TNFSF10 Protein, Fc Tag, active trimer (MALS verified)

Product Sizes
100 ug
£360.00
TRL-H5263-100UG
1 mg
£2385.00
TRL-H5263-1MG
About this Product
SKU:
TRL-H5263
Buffer:
PBS
Extra Details:
TRAIL, also known as TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A and TNF superfamily member 10. The TRAIL gene as a drug target, induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation.
Immunogen:
TRAIL
Molecular Weight:
86.4 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human TRAIL Protein, Fc Tag, active trimer on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human TRAIL Protein, Fc Tag, active trimer (Cat. No. TRL-H5263) at 5 ug/mL (100 uL/well) can bind Human TRAIL R3 protein, His Tag (Cat. No. TR3-H52H3) with a linear range of 5-39 ng/mL (QC tested).