Biotinylated Human TRAIL R2 / DR5 / TNFRSF10B Protein, Avitag[TM],His Tag (MALS verified)
Product Sizes
25 ug
£377.00
TR2-H82E6-25UG
200 ug
£1614.00
TR2-H82E6-200UG
About this Product
- SKU:
- TR2-H82E6
- Additional Names:
- CD262|DR5|KILLER|TNFRSF10B|TRAIL-R2|TRAILR2|TRICK2|TRICKB|ZTNFR9
- Buffer:
- PBS
- Conjugate:
- Biotin
- Extra Details:
- Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
- Immunogen:
- TRAIL R2
- Molecular Weight:
- 16.9 kda
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
