Biotinylated Human TNFR1 / CD120a / TNFRSF1A Protein, His,Avitag[TM] (MALS verified)
Product Sizes
25 ug
£371.00
TN1-H82E4-25UG
200 ug
£1620.00
TN1-H82E4-200UG
About this Product
- SKU:
- TN1-H82E4
- Buffer:
- PBS
- Conjugate:
- Biotin
- Extra Details:
- Tumor necrosis factor receptor 1 (TNF-R1) is also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial Hibernian fever (FHF).
- Immunogen:
- TNFR1
- Molecular Weight:
- 14.6 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
