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Proteins and Peptides

Human & Mouse TNFR1 / CD120a / TNFRSF1A (30-125 & 126-212) Protein, His Tag (MALS verified)

Product Sizes
100 ug
£318.00
TN1-H52H3-100UG
1 mg
£2355.00
TN1-H52H3-1MG
About this Product
SKU:
TN1-H52H3
Buffer:
PBS
Extra Details:
Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).
Immunogen:
TNFR1
Molecular Weight:
22.2 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human & Mouse TNFR1 (30-125 & 126-212) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human & Mouse TNFR1 (30-125 & 126-212) Protein, His Tag (Cat. No. TN1-H52H3) at 5 ug/mL (100 uL/well) can bind Human TNF-alpha Protein, Fc Tag (Cat. No. TNA-H5255) with a linear range of 0.06-2 ng/mL (QC tested).
Immobilized Mouse TNF-alpha Protein, Fc Tag (Cat. No. TNA-M5257) at 5 ug/mL (100 uL/well) can bind Human & Mouse TNFR1 (30-125 & 126-212) Protein, His Tag (Cat. No. TN1-H52H3) with a linear range of 0.004-0.125 ug/mL (QC tested).