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Proteins and Peptides

Biotinylated Human TGF-beta RII / TGFBR2 Protein, His,Avitag[TM] (HPLC verified)

Product Sizes
25 ug
£377.00
TG2-H82E4-25UG
200 ug
£1614.00
TG2-H82E4-200UG
About this Product
SKU:
TG2-H82E4
Additional Names:
TbetaR-II|TGFBR2|TGFR2|TGFB BetaR2
Buffer:
PBS
Conjugate:
Biotin
Extra Details:
TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFB BetaR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-B Beta1 / TGFB1 and TGF-B Beta3 / TGFB3 with high affinity and TGF-B Beta2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
Immunogen:
TGF-beta RII
Molecular Weight:
19.1 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
Biotinylated Human TGF-beta RII, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) at 1 ug/mL (100 uL/well) can bind Biotinylated Human TGF-beta RII, His,Avitag (Cat. No. TG2-H82E4) with a linear range of 5-78 ng/mL (QC tested).
Serial dilutions of Human TGF-beta RII, His Tag (Cat. No. TG2-H52H5) were added into Human Latent TGFB1, His Tag (Cat. No. TG1-H524x) : Biotinylated Human TGF-beta RII, His,Avitag (Cat. No. TG2-H82E4) binding reactions. The half maximal inhibitory concentration (IC50) is 0.39287 ug/mL (Routinely tested).