Human STAT3 Protein, His Tag (MALS & SPR verified)
Product Sizes
100 ug
£419.00
ST3-H5149-100UG
500 ug
£1272.00
ST3-H5149-500UG
About this Product
- SKU:
- ST3-H5149
- Additional Names:
- signal transducer and activator of transcription 3|STAT3
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH7.5
- Extra Details:
- Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes important for essential cellular processes including survival, proliferation, self-renewal, angiogenesis, and immune response. As an early tumor diagnostic marker, it is considered that constitutive STAT3 activation is a sufficient factor to cause malignant transformation and tumor development in model systems. The classical IL-6/STAT3 signaling pathway in cancer cells. IL-6 binds to the membrane-bound IL-6 receptor A Alpha (IL-6R) and IL-6 receptor B Beta (also known as gp130). The IL-6/IL-6R/gp130 complex activate the phosphorylation of JAKs, followed by STAT3 phosphorylation and activation. Then, phosphorylated STAT3 forms a homodimer and translocates into the nucleus to bind to the promotor region of target genes and activates target gene transcription.
- Immunogen:
- STAT3
- Molecular Weight:
- 66.4 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
