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Proteins and Peptides

SARS-CoV-2 Spike Trimer Protein (G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N), His Tag (MALS verified)

Product Sizes
50 ug
£471.00
SPN-C52HS-50UG
500 ug
£3274.00
SPN-C52HS-500UG
About this Product
SKU:
SPN-C52HS
Additional Names:
S glycoprotein|S protein|Spike|Spike glycoprotein
Buffer:
0.1 M Sodium citrate, pH5.5
Extra Details:
SARS-CoV-2 Spike Trimer, His Tag (SPN-C52Hs) is the ectodomain of SARS-CoV-2 spike protein which contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). Mutations G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N were identified in the SARS-CoV-2 Lambda variant (Pango lineage: C.37). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
Immunogen:
Spike protein
Molecular Weight:
137.3 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SARS-CoV-2 Spike Trimer, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized SARS-CoV-2 Spike Trimer, His Tag (Cat. No. SPN-C52Hs) at 1 ug/mL (100 uL/well) can bind Human ACE2, Fc Tag (Cat. No. AC2-H5257) with a linear range of 0.1-6 ng/mL (QC tested).
Immobilized SARS-CoV-2 Spike Trimer, His Tag (Cat. No. SPN-C52Hs) at 1 ug/mL (100 uL/well) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Cat. No. S1N-M122) with a linear range of 0.1-3 ng/mL (Routinely tested).