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Proteins and Peptides

SARS-CoV-2 Spike Trimer Protein, His Tag (BA.1.1/Omicron) (MALS verified)

Product Sizes
50 ug
SPN-C5224-50UG
500 ug
SPN-C5224-500UG
About this Product
SKU:
SPN-C5224
Additional Names:
S glycoprotein|S protein|Spike|Spike glycoprotein
Buffer:
PBS
Extra Details:
SARS-CoV-2 Spike Trimer, His Tag (BA.1.1/Omicron) (SPN-C5224) is the ectodomain of SARS-CoV-2 spike protein which contains AA Val 16 - Pro 1213 (Accession # QHD43416.1(A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P)). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.1.1; GISAID clade: GRA; Nextstrain clade: 21K). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
Immunogen:
Spike protein
Molecular Weight:
138.2 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
SARS-CoV-2 Spike Trimer, His Tag (BA.1.1/Omicron) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized SARS-CoV-2 Spike Trimer, His Tag (BA.1.1/Omicron) (Cat. No. SPN-C5224) at 1 ug/mL (100 uL/well) can bind Human ACE2, Fc Tag (Cat. No. AC2-H5257) with a linear range of 0.4-25 ng/mL (QC tested).
Immobilized SARS-CoV-2 Spike Trimer, His Tag (BA.1.1/Omicron) (Cat. No. SPN-C5224) at 1 ug/mL (100 uL/well) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (Cat. No. S1N-M122) with a linear range of 0.4-25 ng/mL (Routinely tested).