Monoclonal Anti-SN38 Antibody, Mouse IgG1
Product Sizes
100 ug
£630.00
SN8-M685-100UG
1 mg
£4234.00
SN8-M685-1MG
About this Product
- SKU:
- SN8-M685
- Application:
- ELISA, Immunoassay
- Buffer:
- PBS (pH 7.4)
- Clonality:
- Monoclonal
- Extra Details:
- SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form. SN-38 and its glucuronide are lost into the bile and intestines. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.
- Immunogen:
- SN38
- Physical State:
- Powder
- Purification:
- 90%
- Reactivities:
- Mouse
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Antibody: Monoclonal Antibody
