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Rat Siglec-15 / CD33L3 Protein, His Tag (MALS verified)

Product Sizes
100 ug
£371.00
SG5-R52H3-100UG
1 mg
£2703.00
SG5-R52H3-1MG
About this Product
SKU:
SG5-R52H3
Buffer:
PBS, 0.5 M Arginine, pH7.4
Extra Details:
Siglec-15 is a transmembrane glycoprotein belonging to the Siglec family, recognized for its sialic acid-binding properties and role in immune regulation. Structurally, its extracellular domain contains two Ig-like domains, and it functionally associates with the signaling adaptors DAP12 and DAP10. Siglec-15 is expressed on immune cells, including osteoclasts, macrophages, and dendritic cells. It exerts its function by binding to its ligand, the sialyl-Tn antigen. This interaction is critical for inducing TGF-beta production by tumor-associated macrophages and plays an essential role in osteoclast formation and TRANCE/RANK Ligand signaling.
Immunogen:
Siglec-15
Molecular Weight:
27.4 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Lectins
Rat Siglec-15 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Rat Siglec-15 Protein, His Tag (Cat. No. SG5-R52H3) at 1 ug/mL (100 uL/well) can bind Mouse Human chimeric mAb (5G12, Human IgG1) with a linear range of 0.06-2 ng/mL (QC tested).