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Human Siglec-15 / CD33L3 Protein, His Tag (MALS verified)

Product Sizes
100 ug
SG5-H52H3-100UG
1 mg
SG5-H52H3-1MG
About this Product
SKU:
SG5-H52H3
Additional Names:
CD33 antigen-like 3|CD33L3|sialic acid-binding Ig-like lectin 15|SIGLEC-15|Siglec15
Buffer:
50 mM MES, 150 mM NaCl, 0.5 M Arginine, pH5.5
Extra Details:
Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
Immunogen:
Siglec-15
Molecular Weight:
28.4 kda
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Lectins
Human Siglec-15, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human Siglec-15, His Tag (Cat. No. SG5-H52H3) at 1 ug/mL (100 uL/well) can bind Mouse Human chimeric mAb (5G12, Human IgG1) with a linear range of 0.2-2 ng/mL (QC tested).
Immobilized Human Siglec-15, His Tag (Cat. No. SG5-H52H3) at 10 ug/mL (100 uL/well) can bind Neu5Ac(a2-6)GalNAc-PAA-biotin with a linear range of 0.078-0.313 ug/mL (Routinely tested).