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Proteins and Peptides

Human SDF-1 / CXCL12 Protein, Research Grade

Product Sizes
20 ug
£206.00
SD1-H5116-20UG
50 ug
£313.00
SD1-H5116-50UG
1 mg
£2585.00
SD1-H5116-1MG
About this Product
SKU:
SD1-H5116
Buffer:
PBS
Extra Details:
Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells
Immunogen:
SDF-1
Molecular Weight:
8.1 kda
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human SDF-1 Protein, Research Grade on SDS-PAGE under reducing (R) and under non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human SDF-1 Protein, Research Grade (Cat. No. SD1-H5116) at 5 ug/mL (100 uL/well) can bind Human CXCR4, Fc Tag (Cat. No. CX4-H5269) with a linear range of 0.04-2.5 ug/mL (Routinely tested).