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Biotinylated Human Prolactin R / PRLR Protein, His,Avitag[TM] (MALS verified)

Product Sizes
25 ug
£371.00
PRR-H82E3-25UG
200 ug
£1620.00
PRR-H82E3-200UG
About this Product
SKU:
PRR-H82E3
Buffer:
PBS
Conjugate:
Biotin
Extra Details:
The prolactin receptor (PRLR) is a transmembrane protein belonging to the class I cytokine receptor superfamily, widely expressed in mammary gland, reproductive organs, liver, and brain. Signal activation is initiated when a single prolactin (PRL) molecule binds to this pre-dimerized PRLR, inducing a specific conformational change. This triggers the associated JAK2 kinases to phosphorylate each other and the receptor, ultimately leading to the recruitment and activation of downstream STAT5 transcription factors. This precise mechanism governs essential physiological processes, including lactation, reproduction, metabolism, and immune function, and its dysregulation is implicated in diseases such as certain cancers and endometriosis.
Immunogen:
Prolactin R
Molecular Weight:
28.0 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
Biotinylated Human Prolactin R Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human Prolactin Protein, Mouse IgG2a Fc Tag (Cat. No. PRN-H5257) at 5 ug/mL (100 uL/well) can bind Biotinylated Human Prolactin R Protein, His,Avitag (Cat. No. PRR-H82E3) with a linear range of 1-39 ng/mL (QC tested).