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Proteins and Peptides

Human PDGF R beta / CD140b Protein, Fc Tag

Product Sizes
100 ug
£318.00
PDB-H5259-100UG
1 mg
£2314.00
PDB-H5259-1MG
About this Product
SKU:
PDB-H5259
Additional Names:
CD140B|JTK12|PDGF-R-beta|PDGFR-2|PDGFR-beta|PDGFR-B Beta|PDGFRB
Buffer:
PBS
Extra Details:
Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) is also called J03278, M21616, CD140B, JTK12, PDGF-R-beta and PDGFR, is receptor that binds specifically to PDGFB and has a tyrosine-protein kinase activity. Is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. The PDGFR/PDGF system includes two receptors (PDGFRA and PDGFRB) and four ligands (A, B, C and D). The receptors PDGFRA and PDGFRB are related in sequence and both are members of the class III subtype of receptor tyrosine kinases (RTKs). Other class III RTKs are CSF1R, KIT and FLT3. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the A Alpha and B Beta receptors is independently regulated in various cell types. Recombinant soluble PDGFRB binds PDGF with high affinity and is potent PDGF antagonist. The ligands form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-A Alpha and -B Beta. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -A AlphaA Alpha, -B BetaB Beta and -A AlphaB Beta. PDGF-CC specifically interacts with PDGFR-A AlphaA Alpha and -A AlphaB Beta, but not with -B BetaB Beta, and thereby resembles PDGF-AB. PDGF-DD binds to PDGFR-B BetaB Beta with high affinity, and to PDGFR-A AlphaB Beta to a much lower extent and is regarded as PDGFR-B BetaB Beta specific. PDGF-AA binds only to PDGFR-A AlphaA Alpha, while PDGF-BB is the only PDGF that can bind all three receptor combinations with high affinity.
Immunogen:
PDGF R beta
Molecular Weight:
83.1 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
Human PDGF R beta, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human PDGF-BB, premium grade (Cat. No. PDB-H4112) at 1 ug/mL (100 uL/well) can bind Human PDGF R beta, Fc Tag (Cat. No. PDB-H5259) with a linear range of 0.6-10 ng/mL (QC tested).