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Proteins and Peptides

Hamster PCSK9 Protein, His Tag

Product Sizes
50 ug
£277.00
PC9-H52E4-50UG
1 mg
£2314.00
PC9-H52E4-1MG
About this Product
SKU:
PC9-H52E4
Additional Names:
FH3|HCHOLA3|LDLCQ1|NARC1|PC9|PCSK9
Buffer:
PBS
Extra Details:
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Immunogen:
PCSK9
Molecular Weight:
13.9 kDa and 59.0 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
Hamster PCSK9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human LDL R, Fc Tag at 5 ug/mL (100 uL/well) can bind Hamster PCSK9, His Tag (Cat. No. PC9-H52E4) with a linear range of 0.078-0.313 ug/mL (QC tested).
Immobilized Hamster PCSK9, His Tag (Cat. No. PC9-H52E4) at 1 ug/mL (100 uL/well) can bind Evolocumab with a linear range of 2-63 ng/mL (Routinely tested).