Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Proteins and Peptides

Biotinylated Cynomolgus PCSK9 Protein, His,Avitag[TM] (MALS verified)

Product Sizes
25 ug
£371.00
PC9-C82E3-25UG
200 ug
£1619.00
PC9-C82E3-200UG
About this Product
SKU:
PC9-C82E3
Buffer:
PBS
Conjugate:
Biotin
Extra Details:
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Immunogen:
PCSK9
Molecular Weight:
75.1 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
Biotinylated Cynomolgus PCSK9 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Biotinylated Cynomolgus PCSK9 Protein, His,Avitag (Cat. No. PC9-C82E3) at 1 ug/mL (100 uL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 ug/well) plate can bind Human LDL R, Fc Tag (Cat. No. LDR-H5251) with a linear range of 0.06-1 ng/mL (QC tested).
Immobilized Cynomolgus LDL R, His Tag (Cat. No. LDR-C5222) at 5 ug/mL (100 uL/well) can bind Biotinylated Cynomolgus PCSK9 Protein, His,Avitag (Cat. No. PC9-C82E3) with a linear range of 0.2-16 ng/mL (Routinely tested).