SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag
Product Sizes
100 ug
£412.00
NS1-C51H7-100UG
1 mg
£2,953.00
NS1-C51H7-1MG
About this Product
- SKU:
- NS1-C51H7
- Additional Names:
- Host translation inhibitor nsp1|Leader protein|NSP1
- Buffer:
- PBS, Arginine, pH7.4
- Extra Details:
- The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
- Molecular Weight:
- 21.7 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes