Skip to content

Basket

You currently have no items in your basket.

Total (excl. vat) £0.00
View basket & checkout
Proteins and Peptides

Human NOTCH2 Protein, Fc Tag (MALS verified)

Product Sizes
100 ug
£413.00
NO2-H5255-100UG
1 mg
£2703.00
NO2-H5255-1MG
About this Product
SKU:
NO2-H5255
Additional Names:
hN2|N2ECD|NOTCH2
Buffer:
PBS
Extra Details:
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .
Immunogen:
NOTCH2
Molecular Weight:
80.5 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human NOTCH2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human DLL4, His Tag (Cat. No. DL4-H5227) at 5 ug/mL (100 uL/well) can bind Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) with a linear range of 5-78 ng/mL (QC tested).
Immobilized Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) at 1 ug/mL (100 uL/well) can bind Bispecific Antibody (NOTCH2 x NOTCH3) with a linear range of 1-20 ng/mL (Routinely tested).