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Biotinylated Human NOTCH1 Protein, Fc Tag, ultra sensitivity (primary amine labeling)

Product Sizes
25 ug
£966.00
NO1-H8253-25UG
200 ug
£2214.00
NO1-H8253-200UG
1 mg
£5034.00
NO1-H8253-1MG
About this Product
SKU:
NO1-H8253
Buffer:
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Conjugate:
Biotin
Extra Details:
NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
Immunogen:
NOTCH1
Molecular Weight:
80 kDa
Physical State:
Liquid
Shipping Conditions:
Dry Ice
Storage Conditions:
-70[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
Biotinylated Human NOTCH1 Protein, Fc Tag, primary amine labeling on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human DLL4 Protein, Fc Tag (Cat. No. DL4-H5259) at 2 ug/mL (100 uL/well) can bind Biotinylated Human NOTCH1 Protein, Fc Tag, primary amine labeling (Cat. No. NO1-H8253) with a linear range of 2-25 ng/mL (QC tested).