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Proteins and Peptides

Human NOTCH1 Protein, His Tag, premium grade

Product Sizes
100 ug
£377.00
NO1-H52H3-100UG
1 mg
£2461.00
NO1-H52H3-1MG
About this Product
SKU:
NO1-H52H3
Buffer:
PBS
Extra Details:
NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
Immunogen:
NOTCH1
Molecular Weight:
55.4 kda
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human NOTCH1 Protein, His Tag, premium grade on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human DLL4 Protein, Fc Tag (Cat. No. DL4-H5259) at 5 ug/mL (100 uL/well) can bind Human NOTCH1 Protein, His Tag, premium grade (Cat. No. NO1-H52H3) with a linear range of 0.02-0.313 ug/mL (QC tested).
Immobilized Human NOTCH1 Protein, His Tag, premium grade (Cat. No. NO1-H52H3) at 5 ug/mL (100 uL/well) can bind Human DLL4 Protein, Fc Tag (Cat. No. DL4-H5259) with a linear range of 0.3-10 ng/mL (Routinely tested).