Biotinylated Human MR1&B2M Complex Protein (MALS verified)
Product Sizes
25 ug
£185.00
MRM-H82W5-25UG
200 ug
£731.00
MRM-H82W5-200UG
About this Product
- SKU:
- MRM-H82W5
- Buffer:
- PBS
- Conjugate:
- Biotin
- Extra Details:
- MR1 is also knwon as MHC class I-related gene protein. Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers. Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively.
- Immunogen:
- MR1 & B2M
- Molecular Weight:
- 36.3 kDa and 11.7 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
