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Proteins and Peptides

Human LRP-6 (20-630) Protein, Mouse IgG2a Fc Tag

Product Sizes
100 ug
£377.00
LR6-H5253-100UG
1 mg
£2703.00
LR6-H5253-1MG
About this Product
SKU:
LR6-H5253
Additional Names:
LRP-6|LRP6
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Extra Details:
LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. Low-density lipoprotein receptor-related protein 6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.
Immunogen:
LRP-6
Molecular Weight:
95.8 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human LRP-6 (20-630), Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Mouse Dkk-1, His Tag (Cat. No. DK1-M52H6) at 5 ug/mL (100 uL/well) can bind Human LRP-6 (20-630), Mouse IgG2a Fc Tag (Cat. No. LR6-H5253) with a linear range of 10-78 ng/mL (QC tested).
Immobilized Human R-Spondin 1, His Tag (Cat. No. RS1-H4221) at 5 ug/mL (100 uL/well) can bind Human LRP-6 (20-630), Mouse IgG2a Fc Tag (Cat. No. LR6-H5253) with a linear range of 1-20 ng/mL (Routinely tested).