Human LILRA4 / CD85g / ILT7 Protein, His Tag (MALS verified)
Product Sizes
100 ug
LI4-H5243-100UG
1 mg
LI4-H5243-1MG
About this Product
- SKU:
- LI4-H5243
- Additional Names:
- CD85g|ILT-7|ILT7|LILRA4
- Buffer:
- PBS
- Extra Details:
- Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4/ILT7/CD85g) is a marker of plasmacytoid dendritic cells (pDCs), which are reported to be a major source of the abnormally high levels of IFNA Alpha associated with autoimmune diseases. Targeting LILRA4 with therapeutic antibodies to promote killing of these IFNA Alpha-producing pDCs is being investigated as a novel approach to alleviating the symptoms of autoimmune diseases. LILRA4 is an immunoglobulin-like protein preferentially expressed on the surface of human plasmacytoid dendritic cells (pDCs). It interacts with bone marrow stromal cell antigen 2 to control the Toll-like receptor (TLR) driven response by pDCs to viral infection. It may also be involved in modulating pDC-tumour interactions. pDCs are a source of the excess IFNA Alpha which drives autoimmune disease symptoms.
- Immunogen:
- LILRA4
- Molecular Weight:
- 48.5 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
