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Proteins and Peptides

Human LGR5 / GPR49 Protein, His Tag, low endotoxin

Product Sizes
100 ug
£389.00
LG5-H52H3-100UG
1 mg
£2838.00
LG5-H52H3-1MG
About this Product
SKU:
LG5-H52H3
Additional Names:
G-protein coupled receptor 49|G-protein coupled receptor 67|G-protein coupled receptor HG38|GPR49|GPR67|Leucine-rich repeat-containing G-protein coupled receptor 5|LGR5
Buffer:
PBS
Extra Details:
LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/B Beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.
Immunogen:
LGR5
Molecular Weight:
62.0 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human LGR5, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human R-Spondin 3 Protein, Fc Tag (Cat. No. RS3-H5253) at 5 ug/mL (100 uL/well) can bind Human LGR5, His Tag (Cat. No. LG5-H52H3) with a linear range of 10-78 ng/mL (QC tested).
Immobilized Human R-Spondin 1 (21-146), Fc Tag (Cat. No. RS1-H5269) at 5 ug/mL (100 uL/well) can bind Human LGR5, His Tag (Cat. No. LG5-H52H3) with a linear range of 0.02-0.313 ug/mL (Routinely tested).