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Proteins and Peptides

Human LGR5 / GPR49 protein, Fc Tag

Product Sizes
100 ug
£389.00
LG5-H5253-100UG
1 mg
£2585.00
LG5-H5253-1MG
About this Product
SKU:
LG5-H5253
Buffer:
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Extra Details:
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Immunogen:
LGR5
Molecular Weight:
86.8 kda
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human LGR5 protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human R-Spondin 1, His Tag (Cat. No. RS1-H4221) at 5 ug/mL (100 uL/well) can bind Human LGR5 protein, Fc Tag (Cat. No. LG5-H5253) with a linear range of 0.3-10 ng/mL (QC tested).
Immobilized Human LGR5 protein, Fc Tag (Cat. No. LG5-H5253) at 5 ug/mL (100 uL/well) can bind Human R-Spondin 3 (22-146), His Tag (Cat. No. RS6-H5222) with a linear range of 1-20 ng/mL (Routinely tested).