Human LAMP5 / BAD-LAMP Protein, His Tag
Product Sizes
50 ug
£377.00
LA5-H52H9-50UG
500 ug
£2461.00
LA5-H52H9-500UG
About this Product
- SKU:
- LA5-H52H9
- Additional Names:
- BAD-LAMP|Brain and dendritic cell-associated LAMP|LAMP5
- Buffer:
- PBS
- Extra Details:
- LAMPs (lysosome associated membrane proteins) represent a family of glycosylated proteins present predominantly on the membrane of lysosomes whose expression can vary among different tissues, suggesting a separation of functions. LAMP5 is expressed highly and specifically in MLL-r leukemia. LAMP5 is a direct target of the oncogenic MLL-fusion protein. LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo. Functional studies showed that LAMP-5 is a novel modulator of innateimmune pathways in MLL-r leukemias. Downregulation of LAMP5 led to inhibition of NF-K KappaB signaling and increased activation of type-1 interferon signaling downstream of Toll-like Receptor/Interleukin 1 Receptor activation.
- Immunogen:
- LAMP5
- Molecular Weight:
- 25 kDa
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
