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Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His,Avitag[TM]&Tag Free (MALS verified)

Product Sizes
25 ug
£430.00
IT7-H82W4-25UG
200 ug
£1943.00
IT7-H82W4-200UG
About this Product
SKU:
IT7-H82W4
Buffer:
50 mM Tris, 150 mM NaCl, pH7.5
Conjugate:
Biotin
Extra Details:
Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer's patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
Immunogen:
Integrin alpha 4 beta 7
Molecular Weight:
113.1 kDa (ITGA4) & 81.8 kDa (ITGB7)
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
Biotinylated Human ITGA4&ITGB7 Heterodimer Protein, His,Avitag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Biotinylated Human ITGA4&ITGB7 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT7-H82W4) at 1 ug/mL (100 uL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 ug/well) plate can bind Anti-Human Integrin A Alpha 4 B Beta 7 MAb, Human IgG1(ADCC Disable) with a linear range of 0.02-1 ng/mL (QC tested).
Immobilized Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) at 5 ug/mL (100 uL/well) can bind Biotinylated Human ITGA4&ITGB7 Heterodimer Protein, His,Avitag&Tag Free (Cat. No. IT7-H82W4) with a linear range of 0.005-0.156 ug/mL (Routinely tested).