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Proteins and Peptides

Cynomolgus Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)

Product Sizes
100 ug
£495.00
IT7-C52W4-100UG
1 mg
£3433.00
IT7-C52W4-1MG
About this Product
SKU:
IT7-C52W4
Buffer:
50 mM Tris, 150 mM NaCl, pH7.5
Extra Details:
Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer's patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
Immunogen:
Integrin alpha 4 beta 7
Molecular Weight:
111.6 kDa (ITGA4) & 81.6 kDa (ITGB7)
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Cynomolgus ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Cynomolgus ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-C52W4) at 5 ug/mL (100 uL/well) can bind Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) with a linear range of 0.1-8 ng/mL (QC tested).
Immobilized Cynomolgus ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-C52W4) at 1 ug/mL (100 uL/well) can bind Anti-Human Integrin A Alpha 4 B Beta 7 MAb, Human IgG1(ADCC Disable) with a linear range of 0.004-0.125 ug/mL (Routinely tested).