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Proteins and Peptides

Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, His Tag&Tag Free

Product Sizes
100 ug
£436.00
IT2-H53W6-100UG
1 mg
£3374.00
IT2-H53W6-1MG
About this Product
SKU:
IT2-H53W6
Additional Names:
Integrin alpha D beta 2|ITGAD & ITGB2
Buffer:
50 mM Tris, 150 mM NaCl, pH7.5
Extra Details:
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.
Immunogen:
Integrin alpha D beta 2
Molecular Weight:
124.9 kDa | 80.2 kDa
Physical State:
Powder
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C
Supplier:
ACRO Biosystems
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
Human ITGAD&ITGB2 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human ITGAD&ITGB2 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT2-H53W6) at 1 ug/mL (100 uL/well) can bind Human Integrin beta 2/CD18 Antibody with a linear range of 0.3-5 ng/mL (QC tested).