Mouse Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein, Flag Tag&Tag Free
Product Sizes
100 ug
£424.00
IT1-M53D3-100UG
1 mg
£2891.00
IT1-M53D3-1MG
About this Product
- SKU:
- IT1-M53D3
- Buffer:
- 50 mM Tris, 150 mM NaCl, pH8.0
- Extra Details:
- Integrin alpha V beta 1 (A AlphaVB Beta1) is a widely expressed adhesion receptor formed by the non-covalent association of the A AlphaV and B Beta1 (CD29) subunits. Its activity is regulated by a conformational shift from a folded, low-affinity state to an extended, high-affinity state, a process triggered by divalent cations and intracellular signaling. As a canonical RGD-binding integrin, it interacts with ligands including vitronectin, fibronectin, and osteopontin. This interaction is central to its role in mediating cell migration, where its modest binding affinity enables the cyclic attachment and detachment necessary for cell movement. Furthermore, A AlphaVB Beta1 is implicated in cellular differentiation and is co-opted by pathogens, such as foot-and-mouth disease virus, for host cell entry.
- Immunogen:
- Integrin alpha V beta 1
- Molecular Weight:
- 112.3 kDa (ITGAV) & 83.5 kDa (ITGB1)
- Physical State:
- Powder
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C
- Supplier:
- ACRO Biosystems
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
